| 摘要 |
PURPOSE:To industrially and advantageously obtain the subject compound useful as a therapeutic agent for ovarian carcinoma, mastocarcinoma, lung cancer, etc., by culturing a cell or a tissue of a plant capable of producing a taxane type terpene in the presence of a specific jasmonic acid and recovering a formed product from the culture mixture. CONSTITUTION:A cell or a tissue of a plant (e.g. Taxus baccata) capable of producing taxane type terpene is cultured in the presence of a jasmonic acid of formula I {R<1> is a 1-4C alkyl, a group of formula II [R<6> is OH, an OM (M is an alkali metal, an alkaline earth metal or NH4), an NHR<7> (R<7> is H, a 1-4C acyl, a 1-4C alkyl or amino acid residue) or an OR<8> (R<8> is a 1-4C alkyl or a hydrocarbon residue; (n) is an integer of 1-7]; R<2> to R<5> are each H or R<2> and R<3>, R<3> and R<4> or R<4> and R<5> may form a double bond together; R<9> is OH or O-hydrocarbon residue; the fivemembered ring may be further substituted with a hydroxyl group and may form a double bond between adjoining carbon atoms} and a product is recovered to give the objective taxane type perpene (e.g. taxol). |
