PHENYL-ALKYL-CARBOXYLIC ACID-GUANIDINE DERIVATIVES CONTAINING PERFLUOROALKYL-GROUPS, AND PHARMACEUTICAL AND DIAGNOSTICAL COMPOSITIONS CONTAINING THEM

摘要

Perfluoroalkyl-substd. phenylalkanoic acid guanidides of formula (I) and their salts are new: Ra, Rb = H, halogen, CN, OR6, 1-8C alkyl, 3-8C cycloalkyl, Or(CH2)aCbF2b+1 or NR7R8; r = 0 or 1; a = 0-4; b = 1-8; R6-R8 = H, 1-8C alkyl, 3-8C alkenyl, 3-8C cycloalkyl, or phenyl or benzyl opt. substd. by 1-3 of F, Cl, CF3, Me, OMe and NR9R10; R9, R10 = H, 1-4C alkyl or 1-4C perfluoroalkyl; x = 1-3; R1-R5 = H, 1-8C alkyl, 3-8C cycloalkyl, Or(CH2)aCbH2b+1, halogen or CN; provided that≥1 of R1-R5, Ra and Rb = Or(CH2)aCbH2b+1.