发明名称 |
Transdominant negative proto-oncogene |
摘要 |
The present invention provides polynucleotide and polypeptide sequences for a trans-repressing protein of the Fos proto-oncogene family, where the polypeptide is characterized by having a leucine zipper domain and forming a heterodimer with a Jun related protein. This heterodimer is capable of biding to an AP-1 site and suppressing transcriptional transactivation of a promoter containing the AP-1 site.
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申请公布号 |
US5470736(A) |
申请公布日期 |
1995.11.28 |
申请号 |
US19940218686 |
申请日期 |
1994.03.28 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES |
发明人 |
VERMA, INDER M.;WISDOM, RONALD M.;YEN, JONG-YOUNG J. |
分类号 |
C07K14/82;C12N15/12;(IPC1-7):C12N15/12;C12N5/10;C12N15/79;C12N15/86 |
主分类号 |
C07K14/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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