| 发明名称 |
Imidazole 5-position substituted angiotensin II antagonists |
| 摘要 |
Novel substituted imidazoles of Formula (III), which are useful as angiotensin-II antagonists, are disclosed: <IMAGE> (III) These compounds, exemplified by the compound 1-((2'-((i-Amyloxycarbonylamino)sulfonyl)-3-fluoro-(1,1'-biphenyl)-4-yl)methyl)-5-[2-(N-butyryl-N-pyridin-3-ylamino) ethylcarbonyl]-4-ethyl-2-propyl-1H-imidazole, are useful as antihypertensive agents. |
| 申请公布号 |
ZA9403690(B) |
申请公布日期 |
1995.11.27 |
| 申请号 |
ZA19940003690 |
申请日期 |
1994.05.26 |
| 申请人 |
THE DUPONT MERCK PHARMACEUTICAL COMPANY |
发明人 |
JOHN JONAS VYTAUTAS DUNCIA;CAROL LEE ENSINGER;RICHARD ERIC OLSON;MIMI LIFEN QUAN;JOSEPH BASIL SANTELLA III;MARY KATHERINE VANATTEN |
| 分类号 |
C07D233/64;A61K31/415;A61K31/44;A61K31/4427;A61K31/4433;A61K31/445;A61P9/00;A61P9/12;C07C17/14;C07D233/54;C07D233/68;C07D233/90;C07D401/06;C07D401/10;C07D401/12;C07D401/14;C07D403/06;C07D403/10;C07D403/12;C07D409/10;C07D409/12 |
主分类号 |
C07D233/64 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
