| 摘要 |
Nanocapsules typically having a diameter in the range of 20-150 nm are provided and consist of a polymeric shell formed of a surface active poly(alkyl cyanoacrylate) material arranged in one or more layers. The polymeric shell can be composed of a surface active poly(alkyl 2-cyanoacrylate) having general formula (I), wherein R is -CH2-(-CH2-)-mCH3, -CH2-(-CH2-)-mCOOH, -CH2-(-CH2-)-mCOOR', or -CH2CH2-O-(-CH2CH2-O-)-mR'; R' is -CH3, -CH2-(-CH2-)-mCH3, -C-(-CH3-)-2-CH2-C(CH3)3, or -O-Ar; m has a value of from 0 to 20; and n has a value of from 1 to 20, formed by the interfacial polymerisation of self-arranged micelles of the cyanoacrylate monomers. The nanocapsules can be used to encapsulate a wide range of water soluble and water insoluble active agents in high yield for delivery to a target system or locus, for example, drugs for use in therapy or prophylaxis.
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