| 摘要 |
PCT No. PCT/SE91/00154 Sec. 371 Date Sep. 23, 1992 Sec. 102(e) Date Sep. 23, 1992 PCT Filed Feb. 26, 1991 PCT Pub. No. WO91/13092 PCT Pub. Date Sep. 5, 1991.The present invention relates to new vasotocin derivatives with prolonged activity compared to previous vasotocin derivatives. In particular, the vasotocin derivatives of the present invention are of the formula (I) <IMAGE> wherein Hmp is a 2-hydroxy-3-mercaptopropionic acid residue, <IMAGE> Z is Phe or Tyr, Y is Hgn or Hci, X is a residue of the formula <IMAGE> wherein Q is H, alanyl or L-2-aminobutyryl and n is 1, 2 or 3. The present invention also relates to pharmaceutical compositions containing these vasotocin derivatives. |
