| 摘要 |
<p>Disclosed is the identification, cloning and sequencing of flanking DNA regions common to all polysaccharide capsule types in Streptococcus pneumoniae. Also disclosed are particular type-specific genes and gene products that direct the formation of the S. pneumoniae serotype-specific polysaccharide capsule. Methods are provided for detecting S. pneumoniae and for constructing gene cassettes that may be transferred as a unit during transformation and used to direct the expression of specific serotypes of S. pneumoniae capsules.</p> |
