| 摘要 |
This invention provides a method for screening for agents useful for treatment of diseases and pathological conditions affected by cytokines. These agents interact directly or indirectly with an intracellular receptor, which in turn modulates the binding of a rel-like protein, a rel-like protein complex, or other transcriptional proteins to a rel site on the promoter of a cytokine gene. The intracellular receptor can be the estrogen receptor, retinoid acid receptors, retinoid X receptors, glucocorticoid receptor, progesterone receptors, androgen receptor, thyroid hormone receptors, or vitamin D receptor. The select agents can be used to treat osteoporosis, rheumatoid arthritis, inflammation, psoriasis, Kaposi's sarcoma, septic shock and multiple myeloma.
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