MICROPARTICLE DELIVERY SYSTEM

摘要

A particulate carrier for an agent comprising a solid core of a polysacchari de and a proteinaceous material and an organometallic polymer bonded to the core is provided. The agent has a biological activity, such as immunogenicity, and may comprise the proteinace ous material or be a separate component of the core. Polysaccharide cores includ e dextran, starch, cellulose and derivatives thereof and the organometallic polymer includes silicones including substituted silicones. T he particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral administration to produc e immune responses, including antibody responses.