| 摘要 |
<p>Indole derivatives which are steroid 5α-reductase inhibitors of formulae: (I), (II), (III), and the pharmaceutically acceptable salts thereof, wherein R is H or C1-C4 alkyl, R?1, R2, R3, R4, R6, R7 and R8¿ are each independently selected from H, C¿1?-C4 alkyl, halo(C1-C4)alkyl, C1-C4 alkoxy and halo, R?5¿ is H or C¿1?-C4 alkyl, m is 0 or 1, n is 2, 3 or 4, Z is tetrazol-5-yl or CO2R?13¿ where R13 is H or a biolabile ester-forming group, X is methylene, S, O, -SO or -SO¿2?-, R?9 and R10¿ are independently H or C¿1?-C4 alkyl, W is S, O, H/H, H/C1-C4 alkyl or C1-C4 alkyl/C1-C4 alkyl wherein the alkyl groups are the same or different, and R?11 and R12¿ are independently H, C¿1?-C6 alkyl, halo(C1-C6)alkyl, C3-C8 cycloalkyl, aryl or heteroaryl, said cycloalkyl, aryl or heteroaryl optionally being substituted by C1-C6 alkyl, C1-C6alkoxy, halo(C1-C6)alkyl or halo, and R?15¿ is H or C¿1?-C4 alkyl.</p> |
