HETERODIMER POLYPEPTIDE IMMUNOGEN CARRIER COMPOSITION AND METHOD

摘要

Polypeptide compositions comprising two distinct subunits which can form .al pha.-helical coiled-coil heterodimers are described. Th e two subunits can each have a different compound or bioactive moiety attached in a precisely-defined orientation and stoichiometry. In one embodiment of the invention, the polypeptide composition serves as a synthet ic vaccine formulation having a B-cell antigen attached to one subunit, and a T-cell antigen attached to the other subunit.