摘要 |
Biologically active reagents are prepared from particles of copolymers having highly reactive carboxy or equivalent groups. The reagents are prepared by covalently attaching biologically active substances, for example antibodies, to the particles, directly or indirectly through highly reactive carboxy groups on the particle surface. These reagents are used to advantage in analytical elements, methods for the detection of specific binding ligands (such as immunological species) and immunoassays, and in purification methods as affinity chromatography reagents. |
申请人 |
JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC., ROCHESTER, N.Y., US |
发明人 |
SUTTON, RICHARD CALVIN, C/O EASTMAN KODAK CO., ROCHESTER, NY 14650-2201, US;DANIELSON, SUSAN JEAN, C/O EASTMAN KODAK CO., ROCHESTER, NY 14650-2201, US;FINDLAY, JOHN BRUCE, C/O EASTMAN KODAK CO., ROCHESTER, NY 14650-2201, US;OAKES, FRED TERRY, C/O EASTMAN KODAK CO., ROCHESTER, NY 14650-2201, US;OENICK, MARSHA DENISE BALE, C/O EASTMAN KODAK CO., ROCHESTER, NY 14650-2201, US;PONTICELLO, IGNAZIO S., C/O EASTMAN KODAK CO., ROCHESTER, NY 14650-2201, US;WARREN, HAROLD CHESTER, C/O EASTMAN KODAK CO., ROCHESTER, NY 14650-2201, US |