| 摘要 |
<p>A pyrimidine derivative useful as a gastrointestinal movement accelerator and represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein X represents O or NR5, and Y represents O, S or NR5, R5 being hydrogen, C¿1?-C6 alkyl, etc.; R?1 and R2¿ represents each independently hydrogen, C¿1?-C6 alkyl, etc.; R?3¿ represents CN or COOR6, R6 being C¿1?-C6 alkyl, C3-C6 cycloalkyl, aryl, etc.; and R?4¿ represents -SR?7 or -NR8R9¿, wherein R7 represents C¿1?-C6 alkyl, R?8¿ represents C¿1?-C6 alkyl, etc., and R?9¿ represents hydrogen, C¿1?-C6 alkyl, etc., or R?8 and R9¿ together with the nitrogen atom to which they are bonded represent an N-substituted piperazine ring represented by general formula (X), wherein R10 represents C¿1?-C6 alkyl, etc.</p> |
