METHODS AND COMPOSITIONS FOR THE DRY POWDER FORMULATION OF INTERFERONS

摘要

According to the present invention, methods and compositions are provided for spray-dried, interferon-based dry powder composit patticularly interferon-beta. The compositions are useful for treating conditions in humans that are responsive to treatment with interfe? ln pardcular, the methods of the present invention rely on spray drying to produce stable. high-potency dry powder formulation interferonns, including but not limited to IFN-beta. Surprisingly, it has been found that IFN can be prepared in high potency, dry po? formulations by spray drying. Such dry powder formulations find particular utility in the pulmonary delivery of INF.