METHODS OF INDUCING GENE EXPRESSION BY IONIZING RADIATION

摘要

The present invention provides a method for delivering ionizing radiation to specific tissues, resulting in the activation of a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an ecoding region that encodes at least one polypeptide. The radiation source will generally be in the form of a radionuclide, capable of gamma or beta emissions. Processes for regulating polypeptide expression and inhibiting tumor growth using such DNA molecules are also provided.