Laxative compositions.

摘要

A solid, unit dosage form comprises a hard gelatin capsule containing a plurality of multiparticulates each comprising a stimulant laxative and a stool softener. The dosage form may be prepared by:- (a) mechanically working a particulate stimulant laxative agent with a particulate, fusible stool softener in a mixer at a speed and temperature sufficient to melt or soften the stool softener and create particles comprising stool softener containing the particles of laxative agent dispersed therein; (b) milling the resulting agglomerates to obtain particles within a desired size range, (c) blending the particles with lubricant and/or glidant, and (d) filling the particles into a hard gelatin capsule.