Transgenic animals as a model for metabolic bone diseases.

摘要

Transgenic animals (e.g., rat, mouse) carrying a chimeric gene coding diphtheria toxin A chain transduced at a downstream site of the promoter of an osteocalcin gene. The transgenic animals can be used as a model for metabolic bone diseases since they have decreased bone mass associated with a marked reduction in the number of osteoblasts.