| 摘要 |
PURPOSE: To obtain the subject preparation, containing a protein lipid complex in a vesicular form, subjected to a treatment for the inactivation of potentially present viruses and useful for treating blood coagulation disorders containing a coagulation active protein. CONSTITUTION: This stable virally safe preparation contains a protein bound in and/or on lipid vesicles (preferably a coagulation active protein) and is subjected to a treatment for inactivation of potentially present viruses (preferably heat treatment). The preparation preferably contains a blood coagulation factor of an endogenous or an exogenous blood coagulation, preferably an active type blood coagulation factor (e.g. a vitamin K-dependent protein, IIa factor or VIIa factor). The preparation is useful for intravenous injection.
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