发明名称 |
Process for asymmetric total synthesis of camptothecin analogues |
摘要 |
The present invention provides a process for the asymmetric synthesis of camptothecin analogs as well as novel chemical intermediates of Formula I, II, and III. In general, the present process comprises conversion of a cis dioxolanone, having the same desired absolute configuration as the desired camptothecin analog, to a compound of Formula I, II, or III, which compound is then converted to the desired camptothecin analog. <IMAGE> (I) <IMAGE> (I) <IMAGE> (III)
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申请公布号 |
US5468859(A) |
申请公布日期 |
1995.11.21 |
申请号 |
US19940363502 |
申请日期 |
1994.12.23 |
申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
FORTUNAK, JOSEPH;KITTERINGHAM, JOHN;SISTI, NICHOLAS;WOOD, JEFFERY |
分类号 |
C07D487/14;C07D471/14;C07D491/04;C07D491/052;C07D491/22;(IPC1-7):C07D491/22 |
主分类号 |
C07D487/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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