Tetronic, thiotetronic and tetramic acid derivatives as phospholipase A2 inhibitors

摘要

There are disclosed compounds of the formula: <IMAGE> wherein X is O; R1 and R2 are each, independently, hydrogen, C1-C10 alkyl, C3-C20 cycloalkyl, phenylloweralkyl, or substituted phenylloweralkyl substituted by halo, lower alkyl, lower alkoxy, halo lower alkyl, amino, monoloweralkylamino, diloweralkylamino or sulfonamido; A is O, S, NR, or a chemical bond; R, if present, is hydrogen or loweralkyl; m is 0-15; n is 3-12; p is 0-15, where m+p=2-15; and the pharmacologically acceptable salts thereof. Also disclosed is a method for treating immunoimmflammatory conditions in mammals which comprises administering to a mammal so afflicted an effective amount of a compound having the formula above wherein X, R1, R2, A, R, if present, m and p are as listed above and n=3-12 and m+p=2-15.