Molecules influencing the shedding of the TNF receptor their preparation and their use

摘要

Molecules which influence the shedding of the cell-bound p55 Tumor Necrosis Factor receptor (p55-TNF-R), are provided, together with methods of producing them. More particularly, the invention relates to proteases which cleave the cell-bound p55 TNF-R thus creating the soluble receptor and to inhibitors to these proteases comprising sequence asn-172 to thr-182 of p55-TNF-R or muteins thereof.