| 摘要 |
Treatment of conditions of abnormally increased intraocular pressure, particularly those caused by glaucoma, by administration of a phosphonylmethoxypropyl cytosine compound, preferably (S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl) cytosine [HPMPC], is disclosed. The cytosine compounds may be present preferably as a free drug or alternatively encapsulated into liposomes or other :long acting drug delivery systems, Administration of the compound may be by intravitreal injection, aqueous humor injection, injection into the external layers of the eye, such as subconjunctival injection or subtenon injection, or by topical drops, in an inert carrier. The degree of reduction in pressure is dosage-dependent, and significant reduction in pressure is obtained. A single injection is expected to be sufficient to produced prolonged, and perhaps permanent, lowering of the intraocular pressure, although in some cases additional injections may be required at infrequent intervals. The amount of the compound administered may be varied by the physician to obtain the desired degree of pressure decrease. Also disclosed are the compositions used in the method.
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