| 摘要 |
<p>The invention concerns a cyclic ether derivative of formula (I), wherein Ar1 is phenyl or naphthyl, or a 9- or 10-membered bicyclic heterocyclic moiety, and Ar1 may be optionally substituted; A1 includes (1-4C)alkylene; X1 includes oxy; Ar2 includes phenylene, pyridinediyl and pyrimidinediyl which may optionally bear one or two substituents; R?1 and R2¿ together form a group of the formula: -A2-X2-A3- which, together with the carbon atom to which both A?2 and A3¿ are attached, define a 5- or 6-membered ring wherein: A2 is (1-3C)alkylene; X2 includes oxy; and A3 is (1-3C)alkylene; and which ring may be optionally substituted; and Y includes halogeno, 2-cyanovinyl, 2-halogenovinyl, hydroxyimino-(1-4C)alkyl and (1-4C)alkoxyimino-(1-4C)alkyl; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.</p> |
