发明名称 |
PROCESS FOR THE PREPARATION OF MIXTURES OF ISOMERS OF O-PHENOXYALKYLHYDROXYLAMINES OR O-PHENOXYALKYLOXIMES |
摘要 |
A process is disclosed for producing isomer mixtures from Ophenoxyalkylhydroxyl amines Ia: H2N-O-CH2-CH(R1)-O-Ar and Ib: H2N-O-CH(R1)-CH2-O-Ar (wherein R1 represents alkyl, Ar where appropriate a substituted phenyl) and the corresponding salt mixtures. This process involves the following steps: (a) an isomer mixture of O-(2-hydroxyethyl)-oximes (IIa) and (IIb) (in which R2 is an alkyl and R3 is an alkyl or alkoxy, or R2 and R3 together with the common C atom form a 5-7 member ring) is converted by reaction with a sulphonyl halogenide of formula (III): Hal-SO2-R4 (wherein R4 represents an organic group and Hal is a halogen) in the presence of a base to form the corresponding sulphonate mixture of (IVa) and (IVb); (b) this sulphonate mixture is reacted in the presence of a base with a phenol of formula (V): HOAr to produce a mixture of O-phenoxyalkyloximes of general formulae (VIa) and (VIb); (c) the mixture is hydrolysed in the presence of an acid and, if required, (d) the O-phenoxyalkylhydroxyl amines (Ia) and (Ib) are released from the resulting salts using a mineral base. The O-phenoxyalkylhydroxyl amines (Ia/Ib) and their precursors (VIa/VIb) are important intermediate products for plant protective agents and drugs.
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申请公布号 |
CA2189584(A1) |
申请公布日期 |
1995.11.16 |
申请号 |
CA19952189584 |
申请日期 |
1995.04.26 |
申请人 |
BASF AKTIENGESELLSCHAFT |
发明人 |
RANG, HARALD;GOETZ, NORBERT;HARREUS, ALBRECHT;BORCHERS, DIRK;HARTMANN, HORST;MAYWALD, VOLKER;HEIMANN, FRANK;BUSCHULTE, THOMAS |
分类号 |
B01J23/02;B01J31/02;C07B61/00;C07C239/20;C07C249/12;C07C251/54;C07C309/66;(IPC1-7):C07C239/20;C07C253/30;C07C255/54 |
主分类号 |
B01J23/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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