LANTHIONINE-CONTAINING ANTIMICROBIAL COMPOUND

摘要

A lanthionine-containing antimicrobial peptide obtainable from Staphylococcus hyicus strain 664 and pharmaceutically acceptable acid addition salts thereof as well as pharmaceutical compositions comprising said peptide or its acid addition salts and DNA molecules encoding said peptide are described. The peptide is purified from the culture medium of Staphylococcus hyicus strain 664 and can be used in a method of treating or preventing mastitis in a mammal comprising administering to said mammal a pharmaceutically effective amount of the peptide or a pharmaceutically acceptable acid addition salt thereof to effectively treat mastitis or effectively to suppress the rate, severity, and duration of subsequent bacterial infection.