CYCLIC ETHER DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

摘要

The invention concerns a cyclic ether derivative of formula (I), wherein Ar<1> is phenyl or naphthyl, or a 9- or 10-membered bicyclic heterocyclic moiety, and Ar<1> may be optionally substituted; A<1> includes (1-4C)alkylene; X<1> includes oxy; Ar<2> includes phenylene, pyridinediyl and pyrimidinediyl which may optionally bear one or two substituents; R<1> and R<2> together form a group of the formula: -A<2>-X<2>-A<3>- which, together with the carbon atom to which both A<2> and A<3> are attached, define a 5- or 6-membered ring wherein: A<2> is (1-3C)alkylene; X<2> includes oxy; and A<3> is (1-3C)alkylene; and which ring may be optionally substituted; and Y includes halogeno, 2-cyanovinyl, 2-halogenovinyl, hydroxyimino-(1-4C)alkyl and (1-4C)alkoxyimino-(1-4C)alkyl; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.