发明名称 |
COMBINATORIAL DIHYDROBENZOPYRAN LIBRARY |
摘要 |
Combinatorial libraries are disclosed which are represented by the Formula (I): (T'-L)q- S -C(O)-L'-II' wherein S is a solid support; T'-L- is an identifier residue; and -L'-II' is a ligand/linker residue. These libraries contain dihydrobenzopyrans of formula (II) which interact (i.e., as agonists or antagonists) with .alpha. adrenergic receptors, dopamine receptor, .sigma.opiate receptors, and K+ channels and are inhibitors of carbonic anhydrase isozymes. They are useful in the treatment of ocular diseases such as glaucoma.
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申请公布号 |
CA2189634(A1) |
申请公布日期 |
1995.11.16 |
申请号 |
CA19952189634 |
申请日期 |
1995.05.08 |
申请人 |
PHARMACOPEIA, INC. |
发明人 |
BALDWIN, JOHN J.;READER, JOHN C.;DILLARD, LAWRENCE W.;BURBAUM, JONATHAN J.;ZENG, WENGUANG;LI, GE |
分类号 |
C07D491/107;A61K31/35;A61K31/352;A61K31/443;A61K31/445;A61P27/02;A61P27/06;C07B61/00;C07C205/59;C07D311/04;C07D311/08;C07D311/22;C07D311/68;C07D311/96;C07D405/12;C07D407/12;C07D417/12;C07D491/10;C07D493/10;C07D495/10;C07D497/10;(IPC1-7):C07D491/107;C07C201/12;C07D491/20;A61K31/33;C12Q1/527 |
主分类号 |
C07D491/107 |
代理机构 |
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代理人 |
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地址 |
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