THE USE OF FAMOTIDINE AND RELATED COMPOUNDS IN THE TREATMENT OF MOVEMENT DISORDERS

摘要

The present invention relates to methods of treating movement disorders which comprise administering famotidine or a related compound to a subject in need of such treatment. In preferred embodiments of the invention, the movement disorder is associated with an abnormality in basal ganglia structure or function. In a particularly preferred embodiment of the invention, the movement disorder is a component of Parkinson's Disease. The present invention is based, at least in part, on the discovery that Parkinson's Disease patients treated with famotidine reported improved motor function, diminished tremor, and decreased dyskinesias and "on/off" fluctuations in their response to conventional levodopa therapy.