| 摘要 |
This invention relates to novel 2-¢4-(5-substituted-1,2,4-oxadiazol-3-ylmethoxy)benzyl!-1,2,5-oxadiazolidine-3,5-diones which have demonstrated antihyperglycemic activity in diabetic (ob/ob and db/db) mice, genetic animal models of non-insulin dependent diabetes mellitus (NDDM or Type II diabetes). These compounds are represented by Formula (I), wherein R1 is C6-C10 aryl, optionally substituted by one to three substituents independently selected from C1-C6 alkyl, C1-C6 alkoxy, fluorine, chlorine, bromine, iodine, C1-C3 trifluoroalkyl or C1-C3 trifluoroalkoxy; and R2 is selected from the group consisting of hydrogen, C1-C6 alkyl, fluorine, chlorine, bromine, iodine, C1C6 alkoxy, C1-C3 trifluoroalkyl, and C1-C3 trifluoroalkoxy, or a pharmaceutically acceptable salt thereof.
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