| 摘要 |
PURPOSE:To obtain the new compound useful as a radiosensitizer capable of promoting the inactivation by exposing an intractable hypoxic cell present in malignant tumors to radiation. CONSTITUTION:This nitrotriazolylcarboxamide compound is expressed by formula I [X is NH-R1 (R1 is H, a 1-8C alkyl, a hydroxyalkyl or an alkoxyalkyl) or NR2 (R2 is pentamethylene or oxadiethylene)], e.g. 2-(3'-nitro-1'-triazolyl)acetic acid morpholide expressed by formula II. The compound expressed by formula I is obtained by reacting, e.g. 3-nitro-1,2,4-triazole with a halocarboxylic acid ester or an acrylic acid ester, providing a (3-nitro-1,2,4-triazolyl)carboxylic acid ester and then reacting and amidating, etc., the resultant compound with the corresponding amine compound. |
