CYCLIC NUCLEOTIDASE AND PROCESS FOR PRODUCING THE SAME.

摘要

A novel cyclic nucleotidase which is of a type different from that of the known isozyme family is isolated from rat's brain in pure form. It has physicochemical properties such that (1) it acts upon cAMP to form 5'-AMP and upon cGMP to form 5'-GMP; (2) in terms of substrate specificity, it has a Km value of 0.11 mu M against cAMP and a Km value of 1.78 mu M against cGMP; and (3) it has a molecular weight of about 298,000.