8-sulfo-3-quinoline carboxylic acids and process therefore

摘要

This invention is a process for preparing 8-sulfo-7-chloro-6-fluoro-4-oxo-1,4-dihydro-3-quinolinic acid wherein the amino analinomethylenomalonate starting material of Formula 1 is unsubstituted at the R1 and R2 positions i.e. these moieties are hydrogen. In the ring closing process when R1 and R2 are hydrogen, not only does the ring close but the ring position at R2 is sulfonated.