| 摘要 |
The present invention provides compounds of the formula <IMAGE> chelated with a paramagnetic metal ion wherein Z1 and Z2 each represent the atoms necessary to complete a monocyclic or polycyclic carbocyclic or heterocyclic ring system, said Z1 and Z2 independently optionally substituted with R6 and R7, respectively; Rl, R2, R3 and R4 are independently carboxyalkyl (C1-C2), -(CH2)n-C(=O)-NH-R8, or -(CH2)n-C(=O)-O-R8 R5 is carboxyalkyl (C1-C2); R6 and R7 are independently hydrogen, benzyl, or benzyloxy, said benzyl or benzyloxy optionally substituted with one, two or three substituents selected from the group consisting of amino, isocyanato (-N=C=O), isothiocyanato (-N=C=S), -NH-C(=O)-X or -NH-C(=S)-X; R8 is alkyl (C1-C20), -(CH2)m-Ar, or polyhydroxyalkyl (C1-C20); n is 1 or 2; m is 1 to 15; X is a targeting moiety; and Ar is phenyl optionally substituted with one, two or three substituents selected from the group consisting of amino, acylamino, hydroxy, alkyl (C1-C5) and halogen. |
