3 and 5 alkyl and phenyl 4-(hydroxy or acyloxy)-alkyl substituted 2(5h)-furanones as anti-inflammatory agents

摘要

Novel anti-inflammatory furanone compounds have the following formula: where R1 independently is H, or alkyl of 1 to 9 carbons and n is an integer having the values of 1 or 2, and where when n is 1 the R1 group is attached to the 5 position of the 2-furanone, when n is 2 then R1 is attached to both the 3 and 5 positions, with the proviso that when n is 1 then R1 is not H; Y1 is H, alkyl of 1 to 20 carbons, phenyl C1-C20 alkyl, C1-C20 alkenyl containing one or more olefinic bonds, where R3 is H, C1-C20 alkyl, C1-C20 alkenyl containing one or more olefinic bonds, phenyl, halogen substituted phenyl or C1-C6 alkyl substituted phenyl, with the proviso that when Y1 is CO-OR3 or CONHR3 then R3 is not hydrogen; Y2 is H, an alkyl group of 1 to 25 carbons, or phenyl.