METHOD OF USING (H<+>/K<+>) ATPase INHIBITORS AS ANTIVIRAL AGENTS

摘要

A class of compounds which are (H<+>/K<+>) ATPase inhibitors can be used for the treatment of viral infections. Compounds of particular interest are defined by formula (III), wherein D is N or CH; wherein R<7> is one or more radicals selected from hydrido, alkoxy, amino, cyano, nitro, hydroxyl, alkyl, halo, haloalkyl, carboxyl, alkanoyl, nitro, amino, alkylamino, aminocarbonyl, aminosulfonyl, alkylaminocarbonyl, alkylcarbonylamino, alkoxycarbonyl, alkylaminosulfonyl, alkylsulfonylamino, alkylthio, alkylsulfinyl and alkylsulfonyl; wherein R<8> is selected from hydrido, alkyl and cycloalkyl; wherein R<9> is one or more radicals selected from hydrido, alkoxy, amino, alkyl, halo, cyano, nitro, hydroxyl, haloalkyl, nitro, carboxyl, alkanoyl, amino, alkylamino, dialkylamino, aminocarbonyl, alkylaminocarbonyl, alkylcarbonylamino, aminosulfonyl, alkylaminosulfonyl, alkylsulfonylamino, alkoxycarbonyl, alkylthio, alkylsulfinyl and alkylsulfonyl; and wherein R<10> and R<11> are independently selected from hydrido, alkyl, aryl, alkylcarbonyl and arylcarbonyl wherein the aryl ring may be further substituted with one or more radicals selected from alkyl, halo, hydrazidylcarbonyl, aminocarbonyl and alkoxy; or wherein R<10> and R<11> together with the nitrogen atom form a heterocyclic ring; or a pharmaceutically acceptable salt thereof.