TUMOR-ASSOCIATED ANTIGEN PEPTIDES AND THEIR USE IN TUMOR DIAGNOSIS AND THERAPY

摘要

Synthetic peptides of the sequence Phe-Glu-Gln-Asn-Thr-Ala-Gln-X1-X2 wherein X1 is Ala or Pro, and X2 is Gly or OH, and biologically active analogs thereof, are capable of: (i) binding to H-2K<b> molecules on RMA-S cells, (ii) sensitizing RMA-S cells to lysis by specific anti-tumor CTL, (iii) inducing specific CTL in vivo, and (iv) protecting mice from metastasis of 3LL lung carcinoma. These tumor-associated peptides are suitable for tumor diagnosis and therapy, and particularly for treatment of tumor metastasis.