KHELLACTONE DERIVATIVES AND RELATED COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTIVIRAL AND IMMUNOSTIMULATING AGENTS

摘要

Compounds, including compositions and methods of making and using these compounds for treating retroviral infections, are provided according to formula (G-1): wherein M is O or NH; Z is O, NH or S; R<240>, and R<250> are each H, C1-10 alkyl, C1-10 aryl, alkyl, amide, or CH2COOR<260>, where R<260> is C1-10 alkyl or acyl; R<200>, R<210>, R<220> and R<230> are each H, halogen, hydroxyl, NH2, NH-alkyl, N- (alkyl)2, O-alkyl, O-acyl, COCF3, OCF3 or CH2COO NH-alkyl; or R<200> and R<210> form C5-C10 cyclo or heterocyclo optionally substituted with one or more of halogen, hydroxyl, NH2, NH-alkyl, N- (alkyl)<2>, O-acyl, O-alkyl, CO, CF3, OCF3 or CH2 COONH-alkyl; wherein C3 and C4 can be bound by a single or double bond; configurations at 3' or 4' can be (R) or (S); and R<240> and R<250> are either cis- beta or cis- alpha , or trans-3'- alpha or trans-3'- beta oriented.