GUANIDINO-SUBSTITUTED COMPOUNDS

摘要

Novel guanidino-substituted compounds are described having general formula (I) or a salt, hydrate or solvate thereof, in which X is selected from C, O, N and S; R1 and R3 are independently -(W)a-(R6)b-Z, wherein a and b are independently 0 or 1; W is NH, O or S; R6 is C1-8alkylene in which one or two non-adjacent, intervening carbon atoms thereof is optionally replaced with nitrogen or oxygen; and Z is H, OH or -NH-C(NH)-NH2; provided that when b is 0 then Z is H; R2 is selected from H and OH; and R4 and R5 are independently C1-8alkylene in which one of the carbon atoms thereof is optionally replaced with nitrogen or oxygen. Compounds in accordance with formula (I) have been found to inhibit HIV replication.