发明名称 |
LACTONE STABLE FORMULATION OF CAMPTOTHECIN OR 7-ETHYL CAMPTOTHECIN |
摘要 |
Camptothecin (CPT) and 7-ethyl camptothecin (ECPT), are poorly soluble in water. Because of their poor water-solubility, they have not been directly administered by parenteral or oral routes in human patients for the purpose of inhibiting the growth of tumors. The invention provides a pharmaceutically acceptable formulation in the form of an acidic solution or suspension comprising (1) CPT or ECPT, preponderantly in the desired lactone form (1a') (wherein R is hydrogen or ethyl) and (2) dimethylisosorbide or dimethylacetamide.
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申请公布号 |
WO9529677(A1) |
申请公布日期 |
1995.11.09 |
申请号 |
WO1995EP01432 |
申请日期 |
1995.04.18 |
申请人 |
BIONUMERIK PHARMACEUTICALS, INC.;LUCAS, BRIAN, RONALD |
发明人 |
HAUSHEER, FREDERICK, HERMAN;HARIDAS, KOCHAT |
分类号 |
A61K9/08;A61K9/107;A61K9/48;A61K31/47;A61K47/10;A61K47/18;A61K47/26;(IPC1-7):A61K31/47 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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