GENE DELIVERY VECTOR USING PLASMID DNA PACKAGED INTO AN ADENOVIRUS AND A PACKAGING CELL LINE

摘要

This invention provides a novel expression vector useful for inserting and expressing foreign nucleic acid molecules in a host cell. The expression vector of this invention is derived from an adenovirus and has as its components the adenoviral Inverted Terminal Repeat, an adenoviral packaging sequence, and the DNA molecule to be inserted. This invention also provides a pseudo-adenoviral expression vector having a foreign or heterologous DNA molecule inserted within adenoviral capsid proteins. These vectors are useful for gene therapy.