| 摘要 |
<p>Novel bis-1,2-dihydro-3H-dibenzisoquinoline-1,3-diones of formula (I), wherein X, X', Y and Y' are identical or different and are each H, NO2, NH2, C1-C6-alkylamino, di-C1-C6 alkylamino, NH-C1-C6-acyl, OH, C1-H6-alkoxy, halogen trihalomethyl, C1-C6-alkyl, formyl, C1-C6-alkylcarbonyl, ureyl, C1-C6-alkylureyl and A is a C4-C12-bridge which is interrupted at one, two or three points by a secondary or tertiary amino group, where two nitrogen atoms may additionally be bonded to one another by a C1-C4-alkylene group or a salt thereof with a physiologically tolerated acid. Processes for their preparation, pharmaceutical compositions containing them and methods of using them to treat malignancies, mainly human solid tumor carcinomas.</p> |
