PROCESS FOR PREPARATION OF GLYCOSIDES OF TUMOR-ASSOCIATED CARBOHYDRATE ANTIGENS

摘要

Glycoconjugate antigens are prepared by preparing a hapten glycoside, especially an alpha glycoside prepared by the Fischer method, with an olefinic aglycon moiety, especially one having a non-terminal double bond, ozonolyzing the hapten glycoside with an olefinic aglycon moiety having a non-terminal double bond to form a hapten-glycoside derivative, preferably without producing Germaldehyde as a by-product, removing by-products of ozonolysis, and conjugating the hapten-glycoside derivative to a carrier.