METHODS AND COMPOSITIONS FOR MODULATING HETEROTYPIC E-CADHERIN INTERACTIONS WITH T LYMPHOCYTES
摘要
The present invention relates to methods and compositions for modulating the heterotypic adhesion between E-cadherin expressing cells and T lymphocytes. Monoclonal antibodies which specifically bind to E-cadherin and isolated peptides which mimic the binding function of E-cadherin also are provided. The antibodies and peptides are useful in screening assays to identify pharmaceutical lead compounds which are capable of modulating adhesion between T lymphocytes and E-cadherin expressing cells. Methods and pharmaceutical compositions for modifying the mucosal immune response of a subject also are provided.
申请公布号
WO9529693(A1)
申请公布日期
1995.11.09
申请号
WO1995US05518
申请日期
1995.05.03
申请人
BRIGHAM AND WOMEN'S HOSPITAL, INC.;BRENNER, MICHAEL, B.;CEPEK, KARYN, L.