| 摘要 |
<p>PURPOSE:To obtain the compound for antisensitizing agents having nuclease resistance by subjecting a hydroxyl group-protected phenyl-2-deoxy-1-thio-D- ethythro-pentofranoside to coupling reaction with a specific pyrimidine derivative. CONSTITUTION:A hydroxyl group-protected phenyl-2-deoxy-1-thio-D-erythro- pentofranoside expressed by the formula I (R is a hydroxy group-protecting group such as an acyl, benzyl, a trialkylsilyl, a dialkylsilylene or a tetraalkyldisiloxanylidene; Ph is phenyl) is subjected to coupling reaction with a pyridine derivative expressed by the formula II (R<1> is a lower alkyl such as methyl or ethyl; R<2> is H or methyl; X is O or the formula NCOCH3) using an activating agent such as N-bromosuccinic imide to stereoselectively provide the alpha-2'-deoxynucleoside derivative expressed by the formula III (Y is a hydroxyl group or the formula NHCOCH3) and useful as a component for antisense agents having nuclease resistance.</p> |
