发明名称 |
N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
摘要 |
N-(5-isoxazolyl)biphenylsulfonamides and N-(3-isoxazolyl)biphenylsulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(5-isoxazolyl)biphenylsulfonamides and N-(3-isoxazolyl)biphenylsulfonamides and methods for inhibiting the binding of an endothelin peptide to an endothelin receptor or increasing the activity of endothelin peptides by contacting the receptor with a sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.
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申请公布号 |
US5464853(A) |
申请公布日期 |
1995.11.07 |
申请号 |
US19930142159 |
申请日期 |
1993.10.21 |
申请人 |
IMMUNOPHARMACEUTICS, INC. |
发明人 |
CHAN, MING F.;RAJU, BORE G.;CASTILLO, ROSARIO S.;KOIS, ADAM;WU, CHENGDE;BALAJI, VITUKUDI |
分类号 |
C07D261/14;C07D261/16;C07D261/20;C07D413/12;C07D413/14;C07D417/12;(IPC1-7):C07D261/06;A61K31/41 |
主分类号 |
C07D261/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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