5,5'-/(1,3-propanediyl) bis-/imino(2-oxo-2,1-ethanediyl)acetylimino/bis(2,4,6-triiodo-1,3-benzenedicarboxylamides), and contrast media containing them

摘要

PCT No. PCT/EP92/02770 Sec. 371 Date Jun. 1, 1994 Sec. 102(e) Date Jun. 1, 1994 PCT Filed Dec. 1, 1992 PCT Pub. No. WO93/12071 PCT Pub. Date Jun. 24, 1993. <IMAGE> (I) wherein R, R', R1, and R1', which are the same or different, are H, C1-C4 alkyl, linear or branched C1-C4 mono- or polyhydroxyalkyl; R2, R2', R3, and R3', which are the same or different, are one of the groups of formula -CH2CH2OH, -CH2CH(OH) CH2OH -CH(CH2OH)CH(OH)CH2OH, -CH2(CHOH)4CH2OH, or -CH(CH2OH)2; and X is one of the groups -CH(OH)-, -CH(CH2OH)-, -C(OH) (CH2OH)-, or -C(CH2OH)2-, are useful as opacifying components for X-ray contrast media.