发明名称 |
DNA encoding CRF binding protein |
摘要 |
A Corticotropin Releasing Factor-binding protein (CRF-BP) is isolated and purified sufficient to provide AA sequence data from which the DNA is obtained, which is then used to produce the protein recombinantly. The CRF-BP is useful for modulating the biological activity of CRF, such as reducing the high ACTH levels in mammals caused by excess CRF. The CRF-BP or fragments thereof and/or antibodies to the proteins may be employed in diagnostic assays to determine the levels of CRF, CRF-BP and the ratio of CRF/CRF-BP in a vascular fluid sample. The DNA or subsequence thereof can be used as probes for genetic material in certain assays. The anti-CRF-BP antibodies are also useful to purify the CRF-BP protein and to modulate the biological effect of CRF-BPs proteins.
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申请公布号 |
US5464757(A) |
申请公布日期 |
1995.11.07 |
申请号 |
US19930097828 |
申请日期 |
1993.07.23 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES;UNIVERSITY OF READING |
发明人 |
POTTER, ELLEN;BEHAN, DOMINIC P.;FISCHER, WOLFGANG H.;LINTON, ELIZABETH A.;LOWRY, PHILIP J.;VALE, JR., WYLIE W. |
分类号 |
A61K38/00;C07K14/47;C07K16/18;C12N15/12;C12P21/08;G01N33/566;G01N33/68;G01N33/74;(IPC1-7):C12N15/12;C12N15/16;C12N15/63;C07K14/435 |
主分类号 |
A61K38/00 |
代理机构 |
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地址 |
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