| 发明名称 |
MONOCLONAL ANTIBODIES AGAINST TNF-–, HYBRIDOMAS PRODUCING THEM AND METHOD FOR THE PURIFICATION OF TNF-– |
| 摘要 |
A hybridoma cell line is disclosed which cell line expresses a monoclonal antibody which specifically recognizes and binds human TNF-.alpha., the hybridoma being formed by fusion of spleen cells from a mouse previously immunized with human TNF-.alpha. and murine myeloma cells. A monoclonal antibody which specifically recognizes and binds human TNF-.alpha. is also disclosed as well as a process for purification of TNF-.alpha..
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| 申请公布号 |
CA1337518(C) |
申请公布日期 |
1995.11.07 |
| 申请号 |
CA19850498017 |
申请日期 |
1985.12.18 |
| 申请人 |
YEDA RESEARCH AND DEVELOPMENT COMPANY LIMITED;YEDA RESEARCH AND DEVELOPMENT COMPANY LIMITED |
发明人 |
WALLACH, DAVID;HAHN, TALIA;ESHHAR, ZELIG |
| 分类号 |
G01N33/53;A61K35/12;A61K35/14;A61K38/16;A61K38/21;A61K38/36;A61K39/00;A61K39/395;C07K1/22;C07K14/005;C07K14/195;C07K14/47;C07K14/52;C07K16/00;C07K16/18;C07K16/24;C12N5/00;C12N5/10;C12N5/20;C12N15/02;C12P21/00;C12P21/08;C12R1/91;G01N33/569;G01N33/577;(IPC1-7):C12P21/08;C12N5/18;C07K14/525 |
主分类号 |
G01N33/53 |
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