SULFONAMIDE AND SULFONIC ESTER DERIVATIVES EACH HAVING TRICYCLIC HETERO RING.

摘要

Novel antitumor sulfonamide and sulfonic ester derivatives each having a tricyclic hetero ring, represented by general formula (I), and a process for producing the same, wherein G represents a 5- or 6-membered aromatic ring; L represents O or NR<1>, wherein R<1> represents hydrogen or lower alkyl; and M represents a tricyclic structure selected from the members (a), (b), (c), (d), (e), (f), wherein rings A and B represent each a 5- or 6-membered unsaturated ring; X represents NR<2> (wherein R<2> represents hydrogen or lower alkyl) or NHCO; Y represents O, S(O)n, CR<3>R<4>, CO, NR<5>, CHR<6>CHR<7>, CR<8>=CR<9>, NR<1><0>CO, N=CR<1><1>, OCHR<1><2>, S(O)nCHR<1><3> or NR<1><4>CHR<1><5>; and Z represents N or CR<1><6>, wherein n represents 0, 1 or 2; R<3>-R<1><3>, R<1><5> and R<1><6> represent each hydrogen or lower alkyl; and R<1><4> represents hydrogen, lower alkyl or lower acyl. <CHEM>