MOLTEN GRANULATED SUCRALFATE PREPARATION AND PROCESS FOR PRODUCING THE SAME

摘要

A sucralfate preparation prepared by melt granulating a mixture of a sucralfate powder with a water-soluble low-melting wax; and a process for producing a sucralfate preparation by atomizing dry sucralfate, adding a water-soluble low-melting wax to the atomized powder, and heat melting the wax to effect melt (fusion) granulation of the atomized sucralfate. As compared with conventional sucralfate preparations, the above preparation is reduced in the size of dispersed particles, has a high ability to bind plasma proteins, and is remarkably improved in administrability and a protein-binding capacity.